Two new 3,4-secooleanane triterpenoids from Buddleja lindleyana Fort. fruits

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Ya-Shuo Ren, Feng-Qing Xu, Wei Zhang, Pei-Pei Li, Zheng Li, De-Ling Wu In the phytochemical investigation of the fruits of Buddleja lindleyana, two new rare 3,4-secooleanane triterpenoids, 4,23-dihydroxy-3,4-seco-olean-9,12-dien-3-oic acid (1) and 4,23,30-trihydroxy-3,4-seco-olean-9,12-dien-3-oic acid (2), together with nine known compounds (3–11) were isolated. The structures were elucidated primarily by means of extensive spectroscopic analysis. Compounds 1 and 2 have a neuroprotective effect against glutamate-induced neurotoxicity in PC12 cells. Graphical abstract

Source: Phytochemistry Letters - October 28, 2016 Category: Chemistry Source Type: research