P2Y < sub > 1 < /sub > Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells

ConclusionHigh extracellular NaCl induces priming of the NLRP3 inflammasome in RPE cells, in part via P2Y1 receptor signaling. The inflammasome priming effect of NaCl suggests that high intake of dietary salt may promote local retinal inflammation implicated in the development of AMD.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165653

Source: PLoS One - October 26, 2016 Category: Biomedical Science Authors: Philipp Prager Source Type: research

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