Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole

Publication date: Available online 22 October 2016 Source:Environmental Toxicology and Pharmacology Author(s): Bareum Kwon, Younglim Kho, Pan-Gyi Kim, Kyunghee Ji Thyroid endocrine disruption by bisphenol AF (BPAF) alone or in combination with sulfamethoxazole (SMX) exposure was evaluated in adult male zebrafish. Changes in thyroid gene expression were examined using microarrays and were linked to effects on thyroxine hormone production and expression of genes related to the hypothalamic-pituitary-thyroid axis. BPAF alone or in combination with SMX affected genes related to thyroid hormone production and receptor activity, thyroid gland development, and deiodinase activity. Increases in thyroxine levels, and gene expression were more pronounced in the BPAF and SMX mixture group than in the BPAF group. Significant down-regulation of trh and tshβ genes in the brain suggested a negative feedback response resulting in increased thyroxine levels. The present study indicated that BPAF exposure alone alters expression of genes associated with the thyroid endocrine system, and combination with SMX could increase the endocrine disrupting effect of BPAF.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research