Endoplasmic reticulum stress in arterial smooth muscle cells: A novel regulator of vascular disease.

Endoplasmic reticulum stress in arterial smooth muscle cells: A novel regulator of vascular disease.
Curr Cardiol Rev. 2016 Oct 13;
Authors: Furmanik M, Shanahan CM
Abstract
Cardiovascular disease continues to be the leading cause of death in industrialised societies. The idea that the arterial smooth muscle cell (ASMC) plays a key role in regulating many vascular pathologies has been gaining importance, as has the realisation that not enough is known about the pathological cellular mechanisms regulating ASMC function in vascular remodelling. In the past decade endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been recognised as a stress response underlying many physiological and pathological processes in various vascular cell types. Here we summarize what is known about how ER stress signalling regulates phenotypic switching, trans/dedifferentiation and apoptosis of ASMCs and contributes to atherosclerosis, hypertension, aneurysms and vascular calcification.
PMID: 27758694 [PubMed - as supplied by publisher]

Source: Current Cardiology Reviews - October 21, 2016 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research