Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice

Conclusions
We demonstrate for the first time that Sema6D is a target of BMP signalling and that Semaphorin signalling is essential for the initiation of cushion mesenchymal cell formation in the AV canal. Our study reveals a novel BMP-Sema6D-Rho axis regulating AV cushion development.

Source: Cardiovascular Research - October 20, 2016 Category: Cardiology Authors: Peng, Y., Song, L., Li, D., Kesterson, R., Wang, J., Wang, L., Rokosh, G., Wu, B., Wang, Q., Jiao, K. Tags: Cardiac biology and remodelling Source Type: research