Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway.

In conclusion, we provide evidence that OM transcriptionally induces HO-1 via AhR - and H2O2 - independent, but Nrf2 - dependent mechanisms. These results have important implications for human disorders where Nrf2 and HO-1 play a beneficial role.
PMID: 27725188 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - October 6, 2016 Category: Toxicology Authors: Patel A, Zhang S, Shrestha AK, Maturu P, Moorthy B, Shivanna B Tags: Toxicol Appl Pharmacol Source Type: research