Sesquiterpenoids from Ainsliaea spicata and their cytotoxic and NO production inhibitory activities

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Zhi-Ran Shi, Xian-Yuan Zhang, Ren-Tao Zeng, Zhi-Guo Zhuo, Feng Feng, Yun-Heng Shen, Wei-Dong Zhang Four new sesquiterpenes 8α-hydroxy-diaspanolide A (1) and spicatenes A–C (2–4), together with forty known ones (5–44), were isolated from Ainsliaea spicata. Their structures were established on the basis of spectroscopic analysis. All isolates were evaluated for cytotoxicity against three human tumor cell lines 95D, MDA-MB-231, HepG2. The dimeric sesquiterpene lactone 38 showed significant inhibitory activity against three tested human tumor cell lines with IC50 values of 9.10, 3.82, and 1.43μM, respectively. Compound 6 exhibited moderate activity toward MDA-MB-231 and HepG2, with IC50 values of 18.91, and 11.16μM, respectively. Furthermore, four new compounds 1–4 were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, and none of them showed NO production-inhibitory activities (IC50 >30μM). Graphical abstract

Source: Phytochemistry Letters - September 21, 2016 Category: Chemistry Source Type: research