Methodologic Issues when Estimating Risks in Pharmacoepidemiology

AbstractPurpose of ReviewRisk is an important parameter to describe the occurrence of health outcomes over time. However, many outcomes of interest in healthcare settings, such as disease incidence, treatment initiation, and cause-specific mortality, may be precluded from occurring by other events, often referred to as competing events. Here, we review straightforward approaches to estimate risk in the presence of competing events.Recent FindingsWe illustrate the application of these methods using timely examples in pharmacoepidemiologic research and compare results to those obtained using analytic simplifications commonly used to handle competing events.SummaryThese examples demonstrate how the analytic methods used to account for competing events affect the interpretation of results from pharmacoepidemiologic studies.

Source: Current Epidemiology Reports - September 12, 2016 Category: Epidemiology Source Type: research