With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

Publication date: Available online 21 July 2016 Source:Mechanisms of Ageing and Development Author(s): Susanne Drechsler, Marina A Lynch, Susana Novella, Herminia González-Navarro, Silva Hecimovic, Erica Barini, Valter Tucci, Rui E Castro, Roosmarijn E. Vandenbroucke, Marcin Osuchowski, Paul K. Potter Ageing is a complex multifactorial process that results in many changes in physiological changes processes that ultimately increase susceptibility to a wide range of diseases. As such an ageing population is resulting in a pressing need for more and improved treatments across an assortment of diseases. Such treatments can come from a better understanding of the pathogenic pathways which, in turn, can be derived from models of disease. Therefore the more closely the model resembles the disease situation the more likely relevant the data will be that is generated from them. Here we review the state of knowledge of mouse models of a range of diseases and aspects of an ageing physiology that are all germane to ageing. We also give recommendations on the most common mouse models on their relevance to the clinical situations occurring in aged patients and look forward as to how research in ageing models can be carried out. As we continue to elucidate the pathophysiology of disease, often through mouse models, we also learn what is needed to refine these models. Such factors can include better models, reflecting the ageing patient population, or a better phenotypic unders...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research