Treatment of rosacea with topical ivermectin cream: a series of 34 cases.

We report our experience in a series of 34 patients treated with topical ivermectin cream. The results are a reflection of the reality of clinical practice and the perception of patients of the treatment. We also evaluate the efficacy in cases of mild rosacea and erythematotelangiectatic rosacea which have not been studied in trials. PMID: 27617938 [PubMed - as supplied by publisher]
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research

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Background: Rosacea is a chronic inflammatory disease characterized by facial flushing, erythema, edema, and acniform lesions. Recurring flares are common. Moderate and severe rosacea can be disfiguring and psychologically debilitating, difficult to treat, and compromise quality of life. Whole formula nature-based sensitive skin products are formulated to strengthen the skin barrier function and maintain appropriate hydration levels that soothe sensitive skin
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Acne vulgaris and rosacea are common cutaneous disorders associated with psychological distress and impaired quality of life. Little is known about the mental health (MH) comorbidities of these disorders. We sought to determine the prevalence and cost burden of MH disorders associated with acne and rosacea. Data were examined from the 2002-2012 National Inpatient Sample, comprising a ∼20% sample of all US pediatric and adult hospitalizations (n = 87,053,155). Multivariable logistic regression models were constructed with acne or rosacea as the independent variable and each MH disorder as the dependent variable, with ag...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Rosacea is a chronic inflammatory skin disease that is often best managed with combination therapy. There have been a limited number of rigorous controlled studies of combination therapies, despite high interest in such approaches. Doxycycline 40 mg modified release (DMR) and ivermectin 1% cream (IVM) are two well-established treatments for rosacea with proven efficacy, tolerability and safety. DMR and IVM have different and complementary targets in the inflammatory cascade of rosacea, suggesting that this would be a good combination for study.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Ivermectin (IVM) 1% cream represents an emerging topical treatment option for papulo-pustular rosacea (PPR) both for its antiinflammatory and antiparasitic effects. Erythema-directed digital photography is a noninvasive technique that is able to provide more precise evaluation of patient ’s erythema compared with simple clinical inspection or standard clinical photography alone and can optimize treatment outcome. It is a useful tool for evaluation of erythema in inflammatory dermatoses including rosacea.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Rosacea is a common inflammatory skin disease characterized by flares of centrofacial flushing, erythema, and varying presence of papules, pustules, and telangiectasias. Establishing the validity of gastrointestinal (GI) bacterial associations with rosacea is important to test the hypothesis of rosacea presenting as a cutaneous manifestation of a more systemic inflammatory disease. As a systemic inflammatory disease, overgrowth of GI bacterial populations and/or their products may contribute to rosacea symptoms, driving disease flares.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Rosacea is a chronic inflammatory skin disease with potential to adversely impact quality of life (QoL). Those with high disease burden have greater medical needs; identifying high burden (HB) rosacea patients facilitates targeting of medical resources.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Case Report: A 67-year-old woman with a history of rosacea presented with recalcitrant cystic acne. Additionally, the patient reported a 2-year history of gradual scalp hair loss and an increase in facial hair. There was no personal or family history of alopecia, hirsutism, or hyperandrogenism. Physical examination revealed excessive hair on her upper lip, chin, and lateral cheeks. She also had severe frontoparietal hair loss, thinning on the crown, and nodulocystic acne on her chin and cheeks. Laboratory tests showed markedly elevated levels of total testosterone (539 ng/dL), free testosterone (61.8 pg/mL) and DHEA-S (258 ug/dL).
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Contact dermatitis, atopic dermatitis, rosacea, and acne are some of the many skin conditions attributed to a compromised skin barrier. Pathophysiological changes include elevated expression of cytokines, chemokines, impaired skin barrier function, vasodilation of blood vessels and increased blood flow. Reduced expression of epidermal differentiation proteins – filaggrin and occludin, elevated levels of proinflammatory cytokines and nitric oxide (NO), a key regulator in vasodilation of blood vessels, have been shown in individuals with atopic dermatitis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
A 58-year-old woman with past medical history significant for hidradenitis suppurativa (HS) and rosacea presented with a two-year history of numerous asymptomatic light brown to red lesions in the bilateral axillae and inframammary folds. She denied any worsening of her HS or any active or draining cysts. Physical examination revealed clusters of symmetrically distributed hyperkeratotic, red-brown papules with reticulated hyperpigmentation in the bilateral axillae and inframammary folds. Punch biopsy from the left axilla revealed a hyperkeratotic stratum corneum with elongated rete ridges and basilar hyperpigmentation.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Postoperative infection is often diagnosed by the presence of erythema, drainage, and purulence. However, in the absence of culture positivity the clinician should entertain noninfectious inflammatory diagnoses, including rosacea. Here we report two cases of suspected rosacea-like reactions after Mohs surgery that mimicked infection.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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