Richter ’s Transformation in the Era of Kinase Inhibitor Therapy: A Review

Richter ’s transformation (RT) is the transformation of chronic lymphocytic leukemia (CLL) into rapidly progressive b-cell lymphoma. This disease has long been recognized as a difficult-to-treat illness with poor survival outcomes. While the incidence of RT has been well documented in prior literature, le ss is understood in the era of novel therapeutics, namely, kinase inhibitors (KI). This review discusses the current risk factors, incidence, and outcomes of patients with RT in the modern era of KI therapy.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Review Article Source Type: research