The diagnostic value of 11C-methionine PET in hyperparathyroidism with negative 99mTc-MIBI SPECT: a meta-analysis.

CONCLUSION: By merit of the high overall sensitivity, specificity, and accuracy, 11C-methionine PET can potentially complement the diagnostic workup of patients with HPT and negative or inconclusive 99mTc-MIBI SPECT. 11C-methionine PET appears to be a promising diagnostic modality in complicated cases with HPT. PMID: 27589877 [PubMed - as supplied by publisher]
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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AbstractThere are many causes of hypercalcaemia including hyperparathyroidism, drugs, granulomatous disorders and malignancy. Parathyroid hormone (PTH) related hypercalcaemia is most commonly caused by primary hyperparathyroidism (PHPT) and more rarely by familial hypocalciuric hypercalcaemia (FHH). Algorithms for diagnosis of PTH related hypercalcaemia require assessment of a 24-h urinary calcium and creatinine excretion to calculate calcium/creatinine clearance ratio and radiological investigations including ultrasound scan and99mTc-sestamibi-SPECT/CT. To illustrate investigations and management of parathyroid-related hy...
Source: Reviews in Endocrine and Metabolic Disorders - Category: Endocrinology Source Type: research
Abstract There are many causes of hypercalcaemia including hyperparathyroidism, drugs, granulomatous disorders and malignancy. Parathyroid hormone (PTH) related hypercalcaemia is most commonly caused by primary hyperparathyroidism (PHPT) and more rarely by familial hypocalciuric hypercalcaemia (FHH). Algorithms for diagnosis of PTH related hypercalcaemia require assessment of a 24-h urinary calcium and creatinine excretion to calculate calcium/creatinine clearance ratio and radiological investigations including ultrasound scan and 99mTc-sestamibi-SPECT/CT. To illustrate investigations and management of parathyroid...
Source: ENDOCR REV - Category: Endocrinology Authors: Tags: Rev Endocr Metab Disord Source Type: research
Parathyroid carcinoma is uncommon, and its coexistence with parathyroid adenoma is extremely rare. A 28-year-old woman with hyperparathyroidism underwent dual-phase 99mTc-sestamibi SPECT/CT scan for presurgical evaluation. The images showed intense activity inside the left side thyroid and mild activity inside the right side of the thyroid. The histopathologic findings showed intrathyroidal parathyroid carcinoma on the left side and intrathyroid parathyroid adenoma on the right side.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Abstract Reoperative parathyroid surgery (REOPS) is often associated with lower cure rates and greater risk of nerve injury and hypoparathyroidism. The aim of this study was to evaluate cure rates, pathology, complications, and the efficacy of preoperative localization in patients requiring REOPS. Between 1992 and 2017, 2491 consecutive patients underwent parathyroidectomy for primary hyperparathyroidism. With Institutional Review Board approval, our prospectively collected parathyroidectomy outcomes database was queried for operative findings, outcomes, pathology, and localization methodology. Three hundred forty...
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research
DISCUSSION: 18fluorocholine scanning can identify elusive parathyroid adenomas, including those that are ectopic, and is useful in the management of patients with persistent/recurrent primary hyperparathyroidism when first-line scans are negative. The grading of the arterial phase of computed tomography can help to differentiate between true adenomas and false positive targets (lymph nodes). PMID: 31305126 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
Rationale: Secondary hyperparathyroidism (SHPT) is often complicated with chronic renal failure. Though the total parathyroidectomy (TPTX) with forearm autotransplantation (FAT) has been commonly used to treatment refractory renal SHPT, the recurrence of SHPT is not infrequent, resulting from hyperplastic autograft, remnant parathyroid tissues, and supernumerary parathyroid gland (SPG). Patient concerns: A 67-year-old man undergoing TPTX+FAT 4 years previously for renal SHPT, who received regular hemodialysis with active vitamin D supplements of Rocaltrol treatment postoperatively, was admitted to our hospital with pr...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
This study aims to assess the relation between Tc-99m sestamibi parathyroid scan (PS) imaging findings and serum levels of parathormon (PTH) and calcium (Ca) in patients with hyperparathyroidism. Methods: We retrospectively included 57 consecutive patients with hyperparathyroidism (average age of 45.7±13.96 years; 41 (72%) females). All patients underwent PS with early (30 minutes) and delayed (3 hours) phases. SPECT/CT was performed for 43 patients (75%). The Data collected included patients’ demographics, parathyroid hormone (PTH) levels, PS findings, ultrasound (US) findings, surgical and pathological findi...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Tech Papers III: Diagnostic & amp; Therapeutic Nuclear Medicine Source Type: research
The objectives of this study are to further understand the relationship between size of adenoma, perioperative lab values, and surgical outcome. Methods: From 11/2015 - 8/2017, 281 patients underwent SPECT/CT according to institutional protocol with the presumed diagnosis of hyperparathyroidism. Studies were read and dictated by an attending radiologist. Relevant patient information as well as perioperative parathyroid hormone and calcium values were gathered retrospectively. Patients with multigland hyperplasia, MEN syndrome, or without accessible perioperative lab values were also excluded from analysis. Patients were se...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Thyroid and Para-Thyroid Source Type: research
Conclusions: By identifying a tracheoesophageal groove, SPECT/CT could easily identify the descended superior parathyroid lesion that is in fact, located to posterior to the thyroid and posterior to the tracheoesophageal groove. Understanding the relationship between a superior ectopic parathyroid adenoma and recurrent laryngeal nerve in the tracheoesophageal groove is important.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine (GCS) Posters Source Type: research
CONCLUSIONS: For left/right localization of parathyroid adenomas, all modalities performed equivalently. For quadrant localization, technetium Tc99m sestamibi SPECT + multiphase multidetector 4D CT is superior to technetium Tc99m sestamibi SPECT.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: HEAD & amp; NECK Source Type: research
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