Antitrypanosomal activity of iridals from Iris domestica

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Anuradha Liyana Pathiranage, Jeannie Moore Stubblefield, Xiaolei Zhou, Jianhua Miao, Anthony L. Newsome, Norma Dunlap The petroleum ether extract of Iris domestica (Belamcanda chinensis) has been evaluated for activity against Trypanosoma brucei. Bioassay-guided fractionation led to the isolation of four known iridals as the active components. Chemical modification of these isolates afforded novel stable derivatives that maintained bioactivity. This is the first known report of the antitrypanosomal activity of these compounds. Graphical abstract

Source: Phytochemistry Letters - September 3, 2016 Category: Chemistry Source Type: research