Trichothecenes from the fungus Acremonium crotocinigenum BCC 20012

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Taridaporn Bunyapaiboonsri, Seangaroon Yoiprommarat, Sanisa Lapanun, Upin Balram, Rungtiwa Chanthaket, Anupong Klaysuban, Satinee Suetrong Two new trichothecenes (1 and 2) and a new chloroderivative of a trichothecene analogue (3) together with four known trichothecenes, crotocin, trichothecin, 8-deoxytrichothecinol B, and a trichothecene analogue, were isolated from the fungus Acremonium crotocinigenum BCC 20012. The structures of these compounds were elucidated by extensive spectroscopic analysis. Among the tested metabolites, trichothecin itself showed strongest antimalarial activity against Plasmodium falciparum K1, and cytotoxic activity against Vero cell lines with IC50 values of 0.05 and 0.13μg/mL, respectively. Graphical abstract

Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research