A Dendritic Cell-Based Vaccine for CLL in Mice: Targeting the CDR3 Domain of B Cell Receptor

Chronic lymphocytic leukemia (CLL) is characterized by a clonal expansion of mature B-cells in peripheral blood and lymphoid organs. 30% of patients can express BcR with structural similarity in the heavy chain complementarity-determining region 3 (BcR stereotypy). Several stereotyped subsets exist, each defined by a unique HCDR3 motif. Patients belonging to the same subset display similar clinical features. We preliminarily showed that synthetic peptides designed on the consensus sequence of stereotyped HCDR3 were immunogenic in vitro.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research