Targeting mTOR/PI3K in Primary CNS Lymphoma (PCNSL)

The prognosis of PCNSL remains worse than that of other diffuse-large B-cell lymphomas. Thus, there is a big need for further therapeutic improvement. Dysregulation of various cellular pathways, such as NFkB, toll-like receptor or B-cell receptor signaling have been reported in PCNSL and constitute a potential therapeutic target.

Source: Clinical Lymphoma, Myeloma and Leukemia - August 26, 2016 Category: Hematology Authors: Agnieszka Korfel, Elisabeth Schorb, Uwe Schlegel, Sa ša Dimitrijević Dimitrijević, Saana D'Allonzo, Martin Dreyling, Ullrich Herrlinger, Philipp Kiewe Source Type: research