Heat Shock 70 Protein Genes and Genetic Susceptibility to Apical Periodontitis

Heat shock proteins (HSPs) protect cells under adverse conditions such as infection, inflammation, and disease. The differential expression of HSPs in human periapical granulomas suggests a potential role for these proteins in periapical lesion development, which may contribute to different clinical outcomes. Therefore, we hypothesized that polymorphisms in HSP genes leading to perturbed gene expression and protein function may contribute to an individual's susceptibility to periapical lesion development.

Source: Journal of Endodontics - August 25, 2016 Category: Dentistry Authors: Kanwal Maheshwari, Renato M. Silva, Leticia Guajardo-Morales, Gustavo P. Garlet, Alexandre R. Vieira, Ariadne Letra Tags: Clinical Research Source Type: research