Acidification changes affect the inflammasome in human nucleus pulposus cells

Interleukin (IL)-1 β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions,...

Source: Journal of Inflammation - August 24, 2016 Category: Allergy & Immunology Authors: Frank J. Brand, Mahtab Forouzandeh, Harmanpreet Kaur, Francesco Travascio and Juan Pablo de Rivero Vaccari Source Type: research