The estrogen-related receptors (ERRs): potential targets against bone loss.

The estrogen-related receptors (ERRs): potential targets against bone loss.
Cell Mol Life Sci. 2016 Aug 11;
Authors: Zhang L, Wong J, Vanacker JM
Abstract
Bone loss and the resulting skeletal fragility is induced by several pathological or natural conditions, the most prominent of which being aging as well as the decreased levels of circulating estrogens in post-menopause females. To date, most treatments against bone loss aim at preventing excess bone resorption. We here summarize data indicating that the estrogen-related receptors (ERRs) α and γ prevent bone formation. Inhibiting these receptors may thus constitute an anabolic approach by increasing bone formation.
PMID: 27514376 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - August 10, 2016 Category: Cytology Authors: Zhang L, Wong J, Vanacker JM Tags: Cell Mol Life Sci Source Type: research