14-Noreudesmane sesquiterpenes from leaves of Nicotiana tabacum and their antiviral activity

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Shang Shan-Zhai, Zhao Wei, Tang Jian-Guo, Pu Jian-Xin, Zhu Dong-Lai, Yang Liu, Sun Han-Dong, Yang Guang-Yu, Chen Yong-Kuan Three new 14-noreudesmane sesquiterpenes (1–3) as well as four known ones (4–7) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1–7 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 1 exhibited moderate anti-TMV activity with inhibition rate of 46.7%, which were higher than that of positive control (ningnanmycin). Graphical abstract

Source: Phytochemistry Letters - July 23, 2016 Category: Chemistry Source Type: research