Two new quinic acid derivatives and one new lignan glycoside from Erycibe obtusifolia

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Zi-ming Feng, Zhao-zhen Liu, Peng-fei Yang, Ya-nan Yang, Jian-shuang Jiang, Pei-cheng Zhang Three new compounds, 4-{erythro-2-[3-(4-hydroxyl-3-methoxyphenyl)-3-O-β-d-glucopyranosyl-propan-1-ol]}-O-medioresinol (1), (7″E,9″E,1″R*,3″S*,5″R*,6″S*)-5-O-caffeoyl-3-O-dihydrophaseicoylquinic acid (2), and (7″E,9″E,1″R*,3″S*,5″R*,6″S*)-5-O-caffeoyl-4-O-dihydrophaseicoylquinic acid (3), were isolated from Chinese folk herb Erycibe obtusifolia together with six known compounds (4–9). Their structures were elucidated on the basis of comparisons of literatures and extensive spectroscopic analysis, including UV, IR, HRMS, and 1D and 2D NMR techniques. Further, the cytotoxicities of these compounds were evaluated against five cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780), but they were inactive against these tumor cell lines (IC50 >10 μmol/L). Graphical abstract

Source: Phytochemistry Letters - July 23, 2016 Category: Chemistry Source Type: research