Perkiness and fatigue

Sometimes I wake up and am very perky. This annoys my husband to no end so that if I feel the least bit perky I make sure he knows (I love aggravating him sometimes - part of a happy marriage is being able to annoy your spouse).Recently I have been dealing with fatigue. I have no idea why I have so much fatigue but I do. I have had three two hour plus naps in the past five days. This includes sleeping fairly well at night. If this keeps up maybe I should go to the doctor... No wait a minute, I have enough doctor appointments these days. If I make another doctor appointment it will be because I am dripping blood or in so much pain I am unable to move (but then how would I get there if I couldn't move?)Yesterday I had some killer muscle cramps at the gym and was bent over in pain as a result. My hamstrings went into spasm and I could not move. Another woman at the gym noticed and came over to ask if I was okay. I wasn't but I stood still for a while and then tried stretching my hamstrings for a while before I left. When I got home, I went to bed before having lunch. Once I ate, I slept for nearly 2.5 hours.The 'best' thing about fibromyalgia is that pain gets magnified. So when you get muscle cramps, the pain gets magnified.But I digress. If I get enough sleep, I might be perky (and if I am, I make sure my husband knows). But I still might need a nap later in the day. If I don't get enough sleep, I probably won't be perky. The real problem is when I am in too much pain to eat, ...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: being a patient fibromyalgia nap pain levels perkiness Source Type: blogs

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Authors: Ye X, Gray E, Wang YF, Wang SJ Abstract Objectives: To assess the cost-effectiveness of mirogabalin versus no treatment or pregabalin in patients with post-herpetic neuralgia (PHN) from a third-party perspective in Taiwan.Methods: A Markov model, which was developed with 2-week cycles and 1-year time horizon from the Taiwanese National Health Insurance Administration perspective, consisted of three health states: 'mild', 'moderate' and 'severe' pain. Average daily pain score (ADPS) was assessed at the end of each cycle. Patients either remained in, or transitioned from, their assigned health state to a dif...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Conclusions: Valoctocogene roxaparvovec was found to be cost-saving-on average by about $6.8 million per patient-and more effective than prophylactic therapy for treatment of hemophilia A. The comparative benefit of gene therapy was observed across a broad range of simulated patients that were representative of the real-world severe hemophilia A population. PMID: 31971453 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
CONCLUSIONS: High YES1 cytoplasmic expression in EOC patient tissue is significantly correlated with favorable prognosis. Patients with high YES1 expression tend to be sensitive to platinum-based chemotherapy. PMID: 31970720 [PubMed - as supplied by publisher]
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Authors: Wu ZP, Fang HX Abstract The purpose of this paper was to investigate the dynamic trend of SIRT5 (Sirtuins 5) protein expression in gastric cancer cells, for which a hypoxic gastric cancer cell line was established. Afterward, the parental gastric cancer cell group and hypo group were designed, and the levels of related proteins and mRNAs were detected by using Western blot along with real-time quantitative fluorescence PCR (RT-PCR). The results showed that the expression of SIRT5 in hypoxic gastric cancer cells increased significantly, which could increase the phosphorylation level of c-MET (hepatocyte gro...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Rationale: Chronic fatigue syndrome (CFS) is a complicated disorder characterized by severe fatigue that is not relieved with rest and associated with physical symptoms such as sleep problems, headache, muscle pain, or joint pain. Patient concerns: Forty-one year old patient complained from feeling cold after breast cancer surgery. Diagnoses: The diagnoses of fibromyalgia, depression, neurological, psychiatric, and vascular disorders were excluded by appropriate clinical and laboratory investigations. She was diagnosed as CFS. Interventions: The patient was treated successfully via aerobic exercise therapy that schedule...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
I might have mentioned before that I have problems sleeping. This isn't new. I have had problems sleeping since my 30s. But its only recently that it has gotten much more complicated than just a bit of insomnia. Add in things like:Back pain so it can be really hard to get comfortable to sleep at all.Fibromyalgia which causes both fatigue and insomniaRheumatoid painSleep apnea and an evil CPAP machine which keeps me awakeShould I go on? I can....In the past, I have been known to get up and wash the dishes and clean the kitchen in the middle of the night because I couldn't sleep. Trust me, I have been all over the house doin...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: lack of sleep Source Type: blogs
I am very grumpy these days. I think part of it is juggling my medical issues. But its also that I have been dealing with a lot of pain, and in new body parts. I am still on that never ending roller coaster of'wait its another doctor appointment'each week. Also, my stupid CPAP machine doesn't help me. I have given up even using it because the mask doesn't work for me.Last night I almost cancelled all my plans for today to stay home and pout. But I realize pouting never got anyone anything so I ditched that. I did get some good sleep last night which helps. And my reward today is getting my nails done this afternoon after I...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: ailments crabbiness stress Source Type: blogs
This study evaluated antibiotic vs placebo. The study was terminated early due to the determined likelihood that a beneficial effect would not be found. When this was critically analyzed with biostatistical methods, an article was published which I believe demonstrates that Klempner's study was so poorly designed and analyzed that in order for a treatment effect to have been observed, the antibiotic treated patients would have had to improve to a level of health which was a full standard deviation better than the average health of the general population. It's a reasonable hope for antibiotics to return a patient to a somew...
Source: Science - The Huffington Post - Category: Science Source Type: news
We all have had a hangover or few in our lives. Admit it, unless you are a lifetime non-drinker you have had a hangover. Alcoholic hangovers happen. We all know the feelings - dehydrated, headache, general crappy feeling.But with RA and fibromyalgia there are other hangovers - activity hangovers. This happens when I, or anyone with these diseases, attempts to be a normal person. You act normal for one day and then spend three days paying the piper, so to speak.Someone else wrote about activity hangovers the other day which made me feel like I am not alone. She writes about going to a party and then feeling the pain. I, on ...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: doing too much nap normal Source Type: blogs
I have decided I am very aggravated with my health. It drives me crazy. I would be lying if I didn't say that. I would be much happier if I didn't have so many issues. I would be happier if I wasn't in pain. I would be happier if I was able to sleep better. I would be happier if I could do everything that I used to be able to do. I would be happier if I had never had cancer, twice. Or RA or fibromyalgia. Did you know having any one of these cancer, rheumatoid arthritis and fibromyalgia, can cause depression along with everything else? Many people who have a single one of these diseases get diagnosed with depression. So y...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: aggravation ailments coping depression Source Type: blogs
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