Endocrine Disorders Common After Childhood Cancer (CME/CE)

(MedPage Today) -- Thyroid disorders, obesity, diabetes all increase over time
Source: MedPage Today Endocrinology - Category: Endocrinology Source Type: news

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In this study we explored the use of a natural compound rubusoside (RUB) as a solubilizer to enhance the solubility of a fluorescence-labeled C6-Ceramide (NBD C6-Ceramide) and to characterize its pharmacokinetics and tissue distribution in an animal model. RUB significantly enhanced the solubility of NBD C6-Ceramide by forming nanomicelles, and efficiently delivered NBD C6-Ceramide in rats by oral and intravenous administration. RUB loaded 1.96% of NBD C6-Ceramide in the nanomicelles and solubilized it to a concentration of 3.6 mg/mL in water. NBD C6-Ceramide in nanomicelles remained stable in aqueous solutions, all...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Food Composition and AnalysisAuthor(s): Afsaneh Mohajer, Abbas Norouzian Baghani, Parisa Sadighara, Kiandokht Ghanati, Shahrokh NazmaraAbstractIn this current study, the contents of heavy metals including Pb, As, Cr, Cd, Zn, Cu, and Mn in imported rice bran oil in Iran were investigated with microwave digestion method based on an inductively coupled plasma optical emission spectrometry system (ICP-OES). The concentrations range of Pb, Cr, Cd, As, Zn, and Cu in rice bran oil samples were measured as 0.066 - 0.30, 0.008 - 0.014, 0.005 - 0.01, 0.047- 0.01, ...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
Publication date: Available online 10 December 2019Source: Small Ruminant ResearchAuthor(s): J. Reintke, K. Brügemann, H. Wagner, P. Engel, A. Wehrend, S. KönigAbstractThere is an increasing economic pressure in sheep production. Hence, it is imperative to use all available tools contributing to improvements in lamb survival. In this regard, there is a lack of studies addressing the impact of maternal body condition traits on lamb performances during lactation. Specifically, the focus of the present study was to analyse associations between ewe traits reflecting maternal energy metabolism and lamb body weight (LB...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Maunil K. Desai1 and Roberta Diaz Brinton2,3* 1School of Pharmacy, University of Southern California, Los Angeles, CA, United States 2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States 3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
The Growing Toll of Our Ever-Expanding WaistlinesBy  JANE E. BRODY NOV. 13, 2017Paul Rogers I hope you ’re not chomping on a bagel or, worse, a doughnut while you read about what is probably the most serious public health irony of the last half century in this country: As one major killer — smoking — declined, another rose precipitously to take its place: obesity.Many cancer deaths were averted after millions quit lighting up, but they are now rising because even greater numbers are unable to keep their waistlines in check.Today, obesity and smoking remain the two leading causes of pre...
Source: Dr Portnay - Category: Cardiology Authors: Source Type: blogs
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
Conclusions: Developmental exposure to 0.5 μg/kg BW/d of BPA, which is 8–10 times lower than the current preliminary EFSA (European Food Safety Authority) tolerable daily intake (TDI) of 4 μg/kg BW/d and is within the range of environmentally relevant levels, was associated with sex-specific differences in the expression of genes in adipose tissue plasma triglyceride levels in males and adipocyte cell density in females when F344 rat offspring of dams exposed to BPA at 0.5 μg/kg BW/d were compared with the offspring of unexposed controls. https://doi.org/10.1289/EHP505 Received: 13 Ma...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
The rate of late-onset endocrine complications among childhood cancer survivors has risen, with an estimated 50% of survivors experiencing complications ranging from thyroid dysfunction to obesity or type 2 diabetes during their lifetime, according to a study in theJournal of Clinical Oncology.Healio 
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
The obesity epidemic continues to dominate headlines--and for good reason. Obesity is a leading cause of heart disease, diabetes, high blood pressure, and stroke. Many of these conditions occur in adults but often begin in childhood. This September is National Childhood Obesity Awareness Month. By knowing the facts and taking steps to help your children live a healthier lifestyle, childhood obesity and its resulting complications may be prevented. The Facts According to the Centers for Disease Control &Prevention (CDC), one in three children in the U.S. is overweight or obese. Childhood obesity doubled in children a...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Purpose The development of endocrinopathies in survivors of childhood cancer as they age remains understudied. We characterized endocrine outcomes in aging survivors from the Childhood Cancer Survivor Study on the basis of therapeutic exposures. Patients and Methods We analyzed self-reported conditions in 14,290 5-year survivors from the Childhood Cancer Survivor Study, with a median age 6 years (range,
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Long Term Survival & Late Effects, Rapid Communications, Rapid Communications Source Type: research
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