Exercise and the Hypothalamo-Pituitary-Adrenal Axis.

Exercise and the Hypothalamo-Pituitary-Adrenal Axis. Front Horm Res. 2016 Jun 27;47:12-26 Authors: Duclos M, Tabarin A Abstract Exercise represents a potent physiological stimulus upon the hypothalamo-pituitary adrenal (HPA) axis. Two major factors modulate the HPA axis response to exercise: intensity and duration. Endurance training per se does not induce permanent hypercortisolism as endurance-trained subjects have similar biological markers of HPA axis activity in resting condition as healthy untrained men. However, during a challenge of the HPA axis, endurance-trained subjects demonstrate an adaptation of the HPA axis activity to repeated exercise resulting from decreased tissular sensitivity to glucocorticoids. A great diversity of other mechanisms is involved in this adaptation, acting potentially at all levels in the cascade and leading to the biological effects of cortisol. PMID: 27348531 [PubMed - as supplied by publisher]
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research