Cognition and the menopause transition

Complaints about forgetfulness, “brain fog,” and difficulty concentrating are common in women transitioning through menopause. Women with these cognitive complaints often express concern about whether these problems are normal, related to menopause, or represent a symptom of Alzheimer disease or another serious cognitive disorder. In this Practice Pearl, we provide a brief summary of the scientific literature on the frequency of cognitive complaints in midlife women, the validity of complaints in relation to performance on standardized cognitive tests, and the influence of menopause on cognitive performance. We then offer recommendations for healthcare providers and women to address cognitive concerns.
Source: Menopause - Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

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A reduction in reproduction hormones from menopause may reduce cognitive function in women and increase risk for Alzheimer’s, according to a study published in theJournal of Alzheimer’s.News Medical
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
A new PET technique can visualize early Alzheimer's disease by imaging the...Read more on AuntMinnie.comRelated Reading: fMRI shows dementia patients' brain response to music New Alzheimer's definition relies on imaging biomarkers Flortaucipir-PET could lead in early Alzheimer's detection PET study links menopausal status to Alzheimer's FDG-PET links physical activity to healthy brains
Source: Headlines - Category: Radiology Source Type: news
AbstractEstrogens play a crucial physiological function in the brain; however, debates exist concerning the role of estrogens in Alzheimer ’s disease (AD). Women during pre-, peri-, or menopause periods are more susceptible for developing AD, suggesting the connection of sex factors and a decreased estrogen signaling in AD pathogenesis. Yet, the underlying mechanism of estrogen-mediated neuroprotection is unclarified and is complicat ed by the existence of estrogen-related factors. Consequently, a deeper analysis of estrogen receptor (ER) expression and estrogen-metabolizing enzymes could interpret the importance of ...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Contributors : Tutu Oyelami ; An De Bondt ; Ilse Van den Wyngaert ; Kirsten Van Hoorde ; Ilse Dewachter ; John KempSeries Type : Expression profiling by arrayOrganism : Mus musculusThe prevalence of Alzheimer ’s disease is significantly higher in women than in men, with recent estimates suggesting that two thirds of AD patients are females. However, the reason for this is unclear and complex, with the fact that women live longer than men being a likely contributor to the observed disparity. Given the c omplexity of AD and the restrictions in studying any gender-linked biological differences in patients, an establishe...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Authors: Marotta F, Marcellino M, Catanzaro R, Campiotti A, Lorenzetti A, Cervi J, Barbagallo M Abstract During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer's disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The study population consisting of 69 untreated post-menopausal women were given supplements as follows: Group A was given a multivitamin...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Experts examined if brain fog experienced in menopause could be related to Alzheimer's disease. Helen Smith almost left her job at Greater Manchester Police due to the symptom.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 11 February 2020Source: Pharmacological ResearchAuthor(s): Minghua Wu, Min Li, Jun Yuan, Sen Liang, Zhaoyao Chen, Min Ye, Paul M. Ryan, Cain Clark, Shing Cheng Tan, Jamal Rahmani, Hamed kord Varkaneh, Akshaya Srikanth BhagavathulaAbstractHormone therapy continues to be a favourable option in the management of menopausal symptomatology, but the associated risk-benefit ratios with respect to neurodegenerative diseases remain controversial. The study aim was to determine the relation between menopausal hormone therapy and Alzheimer's disease, dementia, and Parkinson's disease in human subjec...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract 17β-Estradiol (estradiol or E2) is a steroid hormone that has been broadly applied as a neuroprotective therapeutic for a variety of neurodegenerative and cerebrovascular disorders such as ischemic stroke, Alzheimer's disease, and Parkinson's disease. Several laboratory and clinical studies have reported that estrogen replacement therapy (ERT) had no effect against these diseases in elderly postmenopausal women, and at worst, increased their risk of onset and mortality. This review focuses on the growing body of data from in vitro and animal models characterizing the potential underlying mechanisms a...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
Conclusion: Our data support a precision medicine approach for further development of PhytoSERM as a safe and effective alternative to hormone therapy for menopause-associated hot flash and cognitive decline. While definitive determination of PhytoSERM efficacy is limited by the small sample size, these data provide a reasonable rationale to extend analyses to a larger study set powered to address statistical significance.
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
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