Pole Vaulter With Cystic Fibrosis Clears Odds For Survival
BOSTON (CBS) — Clearing the bar and the challenges of life and living with cystic fibrosis far longer than anyone thought he would, Jerry Cahill says exercise has made all the difference. He is in Boston for the premiere of a documentary about his extraordinary life. This pole vaulter from New York not only has beaten the odds, he’s crushed them. “I’m 60 years old today, yes,” says Cahill smiling. And that’s a remarkable feat. Jerry was diagnosed with cystic fibrosis when he was a kid. “You build up a bacteria, the mucus gets really thick, and it starts to clog up the airways,” he says. When Jerry was diagnosed the average life expectancy for someone with CF was in the teens. Today it’s 38. “When I was diagnosed the doctors told my parents, you’ll be lucky if your son makes it to his 16th birthday,” Jerry says. Now remember, Jerry is celebrating his 60th birthday today. It’s serious, intense exercise that Jerry thinks has made the difference. “When I got out of college I was a pole vaulter, did a lot of running, gymnastics, weight lifting,” he says. A new documentary called “Up For Air” traces Jerry’s life and struggle with CF and shows how his fitness routine is it’s own form of therapy. “I think it’s the best way of airway clearance is through exercise, and the running and the coughing really helps clear o...
Conclusion: IT following lung and liver transplantation, with injection of islets into a transplanted organ, is feasible. It improves C-peptide secretion, decreases insulin needs, and lowers HbA1c.Horm Res Paediatr
Condition: Lung Transplant Rejection Intervention: Device: photopheresis Sponsors: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico; Italian Cystic Fibrosis Research Foundation Not yet recruiting
Abstract The repurposing of drug delivery by the pulmonary route has been applied to treatment and prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been most successful for the delivery of inhaled bronchodilators and corticosteroids in patients with asthma and chronic obstructive pulmonary disease (COPD). Repurposing utilizes the advantages that the pulmonary route offers in terms of more targeted delivery to the site of action, the use of smaller doses, and a lower incidence of side-effects. Success has been more variable for other drugs and treatment indications. Pulmonary deliv...
Nontuberculous mycobacteria (NTM) are an important emerging threat to cystic fibrosis (CF) patients. In North America, where the incidence of NTM in CF patients is ≥11.8%, Mycobacterium abscessus complex (MABSC), a multidrug-resistant NTM, accounts for ~35% of these , is notoriously recognised as difficult to eradicate, and seriously affects morbidity and mortality in CF  as well as lung transplantation outcomes [3, 4]. The mechanisms for the increased incidence of MABSC infection in CF patients are not known. The immune response in CF patients is directed to the Th2 response, which is associated with poorer clini...
In this study we investigated regulatory t cells after combined lung and liver transplantation, or after isolated lung transplantation, in cystic fibrosis patients and correlated the findings with long term outcomes
Patients with cystic fibrosis (CF) may have pulmonary infection with multi-drug resistant organisms (MDRO) potentially impacting post-transplant mortality. Our objective was to study 1-year mortality in CF patients with MDRO compared to those without MDRO lung transplant recipients (LTR) querying the largest international registry.
Early detection of Mycobacterium abscessus complex (MABSC) is crucial for patients with chronic lung disease to enhance the opportunity for potential eradication. Colonisation with MABSC is an absolute contra indication to lung transplantation in many transplant centres. Isolation of MABSC and other non-tuberculous mycobacteria (NTM) by traditional AFB culture is problematic, particularly from patients with cystic fibrosis (CF). Cultures are frequently overgrown by other bacteria or fungi and sputum decontamination procedures can reduce the viability of NTM.
Lobar lung transplantation is known as an alternative for higher Donor/Receiver mismatch in cystic fibrosis or idiopathic pulmonary fibrosis patients. Using lobar lung transplantation for Pulmonary Hypertension remains questionable because of the higher risk of primary graft dysfunction. We thought to determine wether lobar lung transplantation from brain-dead donors is an option for Pulmonary Hypertension.
This study aims to characterize this acute airway inflammation in association with ACR status.
We report our experience of LTx for CF patients infected with BCC.