Targeting CX3CR1 Reduces Breast Cancer Metastasis

In conclusion, these data support the drug development of CX3CR1 antagonists, and promoting their clinical use will provide novel and effective tools to prevent or contain the progression of metastatic disease in breast cancer patients.
Implications: This work conclusively validates the instrumental role of CX3CR1 in the seeding of circulating cancer cells and is expected to pave the way for pairing novel inhibitors of this receptor with current standards of care for the treatment of breast cancer patients. Mol Cancer Res; 14(6); 518–27. ©2016 AACR.

Source: Molecular Cancer Research - June 14, 2016 Category: Cancer & Oncology Authors: Shen, F., Zhang, Y., Jernigan, D. L., Feng, X., Yan, J., Garcia, F. U., Meucci, O., Salvino, J. M., Fatatis, A. Tags: Cell Death and Survival Source Type: research