Antibodies to adalimumab are associated with future inflammation in Crohn's patients receiving maintenance adalimumab therapy: a post hoc analysis of the Karmiris trial

Conclusions
ATA were detected in 20% of patients. Risk of ATA formation increased with lower early serum ADL concentration and in patients not on IMM. ATA and ADL were strongly associated with higher future CRP level and discontinuation of ADL.

Source: Gut - June 2, 2016 Category: Gastroenterology Authors: Baert, F., Kondragunta, V., Lockton, S., Vande Casteele, N., Hauenstein, S., Singh, S., Karmiris, K., Ferrante, M., Gils, A., Vermeire, S. Tags: Inflammatory bowel disease Source Type: research