Islet Cell Transplantion: Update on Current Clinical Trials

Abstract In the last 15 years, clinical islet transplantation has made the leap from experimental procedure to standard of care for a highly selective group of patients. Due to a risk/benefit calculation involving the required systemic immunosuppression, the procedure is only considered in patients with type 1 diabetes, complicated by severe hypoglycemia or end stage renal disease. In this review, we summarize current outcomes of the procedure and take a look at ongoing and future improvements and refinements of beta cell therapy.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

Related Links:

AbstractAimsTo investigate the long ‐term efficacy and safety of Islet transplantation (ITx) compared to multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII).MethodsAmong 619 patients diagnosed as insulin ‐dependent diabetes mellitus (IDDM) or type 1 diabetes in our hospital, seven patients were selected as the ITx group and 26 age‐matched patients with no endogenous insulin secretion were selected as the MDI/CSII group. HbA1c, AST/ALT and creatinine were assessed retrospectively at 1, 2, 5 and 1 0 years for both groups; serum C‐peptide immunoreactivity (CPR) was assessed for the ITx g...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for huma...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Diagnosed with type 1 diabetes as a child in the 1950s, Robert H. Eckel, didn't want to study his own disease but instead was interested in type 2 diabetes and the'cardiometabolic'consequences.Medscape Medical News
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Diabetes & Endocrinology News Source Type: news
Boron containing compounds promote the survival and the maintenance of pancreatic β-cells. Mol Biol Rep. 2019 Jul 31;: Authors: Aydın S, Demirci S, Doğan A, Sağraç D, Kaşıkcı E, Şahin F Abstract Diabetes mellitus is worldwide disease. The life of diabetic patients are dependent on exogenous insulin. Pancreas or particularly islet transplantations are performed for reducing external insulin dependency. External substances are also used to protect the β-cells from the death or increase insulin secretion. In the current study, two different boron containing compounds (sodium penta...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
ConclusionIn DT1 patients, renal transplantation is the best treatment for ESRD despite the use of corticosteroids and anticalcineurins. However, prior explorations of good cardiac function and adequate vascular compliance are essential to reduce the risk of CV.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Unfortunately there is a mistake in the presentation of the affiliations in this paper.
Source: Diabetologia - Category: Endocrinology Source Type: research
(University of Illinois at Chicago) Surgeons at UI Health have demonstrated that obese patients with Type 1 diabetes can safely receive a pancreas transplant when the surgery is performed robotically.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Type 1 diabetes, characterized by autoimmune destruction of pancreatic beta cells, affects 41 million people worldwide. Beta cell replacement therapies have immense potential as a treatment option because pancreatic progenitors derived from human pluripotent stem cells can provide a near limitless supply of transplantable tissue. The key limitation of this approach is the need for lifelong use of immunosuppressive drugs that have undesirable side effects. Microencapsulation is an option for providing protection for transplanted cells from mechanical stress and immune attack. Traditionally, pluripotent cel...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
AbstractPurpose of ReviewPancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell biology has provided the means to overcome these challenges.Recent Findings3D bioprinting allows for the precise fabrication of complex 3D architectures containing spatially distributed cells, biomaterials (bioink), and bioactive factors. Different strategies to capitalize on this ability have been inves...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
This study identifies the protein tyrosine phosphatase 1B (PTP1B) as a potential modulator of islet graft revascularization. We demonstrate that grafts of pancreatic islets lacking PTP1B exhibit increased revascularization, which is accompanied by improved graft survival and function, and recovery of normoglycemia and glucose tolerance in diabetic mice transplanted with PTP1B-deficient islets. Mechanistically, we show that the absence of PTP1B leads to activation of hypoxia-inducible factor 1α–independent peroxisome proliferator–activated receptor coactivator 1α/estrogen-related receptor α sig...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
More News: Clinical Trials | Diabetes | Diabetes Type 1 | Endocrinology | Transplant Surgery | Transplants