how to titrate iv anest drug in acute patient who needs emergent intubation? time to peak effect?

hi,friends..i often told to always do titration when we want to give a hypnotic drug to an acute patient...it makes sense because they usually need less of it..right? i am curious though..how would you approach that? i was told to always wait for the time to peak effect(ex. propofol: 2-3 mnts) before giving another large dose..what do you think about it? any input or thoughts are welcome..sincerely,Ketap
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