Transient Subfoveal Fluid and Visual Loss after Ocriplasmin.

Conclusions: In the light of the documented adverse effects of the registration trial, the relatively high rate of subfoveal fluid after injecting ocriplasmin was surprising. Possible causes include enzymatic lysis of the matrix between the outer segments of the photoreceptors and the microvilli of the RPE-cells, or barrier disturbances in the RPE through lysis of the zonulae occludentes.
PMID: 27116507 [PubMed - as supplied by publisher]

Source: Klinische Monatsblatter fur Augenheilkunde - April 28, 2016 Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research