Five new steroidal glycosides from the roots of Cynanchum stauntonii

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Kaiming Wang, Ang Li, Ruiling Zhang, Siying Li, Fang Zhang, Lei Zhao, Zhongxi Zhao, Shanzhong Li, Jianhua Cai, Jimin Cao Five new steroidal glycosides, named as stauntosides D1 (1), D2 (2), D3 (3), I1 (4), and I2 (5), were isolated from the 95% ethanol extract of the roots of Cynanchum stauntonii. Their structures were elucidated by extensive spectroscopic analyses, including 1D, 2D NMR, and HRESI–MS, and qualitative chemical methods. All compounds were tested for cytotoxicity against five human tumor cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780) where they were found to be inactive. Their significance in terms of the chemotaxonomy of C. stauntonii is discussed. Graphical abstract

Source: Phytochemistry Letters - April 26, 2016 Category: Chemistry Source Type: research