Cucurbitane-type triterpenoids from the aerial parts of Momordica charantia L.

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Ying Jiang, Xing-Rong Peng, Mu-Yuan Yu, Luo-Sheng Wan, Guo-Lei Zhu, Gao-Ting Zhao, Lin Zhou, Ming-Hua Qiu, Jian Liu Six new cucurbitane-type triterpenoids (1–6), together with two known analogues (7 and 8) were isolated from the aerial parts of Momordica charantia L. The structures of new compounds were identified as cucurbita-6,24-dien-3β,23-diol-19,5β-olide (1), (19R)-5β,19-epoxy-19-methoxycucurbita-6,24-dien-3β,23-diol (2), (19S)-5β,19-epoxy-19-methoxycucurbita-6,24-dien-3β,23-diol (3), (19R)-5β,19-epoxy-19-isopropoxycucurbita-6,24-dien-3β,23-diol (4), 3β,23-dihydroxy-5-methoxycucurbita-6,24-dien-19-al (5) and (19R)-7β,19-epoxy-19-methoxycucurbita-5,24-dien-3β,23-diol (6), by extensive MS, 1D and 2D NMR spectroscopic technologies. This is the first report of the isolation of tetracyclic triterpenoids possessing a 7β,19-epoxy system, viz., 6, from M. charantia L. Graphical abstract

Source: Phytochemistry Letters - April 19, 2016 Category: Chemistry Source Type: research