Extramedullary Plasmacytoma Presenting With Acute Airway Compromise, Treated With Emergent Rigid Bronchoscopic Resection
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Authors: Láinez Ramos-Bossini AJ, Moyano Portillo Á, Ruiz Carazo E PMID: 31447086 [PubMed - as supplied by publisher]
Conditions: Multiple Myeloma in Relapse; Plasmacytoma; Daratumumab Intervention: Drug: Drug Combinations Sponsor: Seoul National University Hospital Recruiting
Primary cutaneous plasmacytoma (PCP) is a rare extramedullary neoplasm, which poses a challenge for dermatologists, hematologists, and dermatopathologists. Since it was first described by Hedinger et al in 1911, there are only 35 solitary documented cases. According to Torne et al, in order to be classified as PCP, lesions must fulfill the following criteria: (1) solitary focus of plasmacytoma proven by biopsy, (2) normal bone marrow findings (less than 10% plasma cells), and (3) no evidence of disseminated disease.
Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasm...
We report a case of solitary tracheal plasmacytoma causing symptoms of airway obstruction in a 59-year-old man. Flow/volume loop indicated the fixed central airway obstruction. Computerized tomography and bronchoscopy demonstrated a sessile tumor on posterior tracheal wall obstructing 80% of the lumen. Partial tracheal resection with T-T anastomosis was performed. Pathologic analysis of resected mass revealed EMP. Additional investigations excluded multiple myeloma. There are no signs of disease recurrence after 7-year follow-up.
This study presents a rare case of tracheal EMP occluding approximately 90% of the lumen that was successfully managed by surgery followed by radiotherapy. Rationale: Extramedullary plasmacytomas (EMPs) are rare solitary soft tissue tumors characterized by monoclonal proliferation of plasma cells. Most lesions occur in the head and neck, but primary tracheal lesions are very rare. Patient Concerns: In this report, we describe a case of tracheal EMP discovered in a 48-year-old man who presented with a history of progressive dyspnea. Diagnoses: Computed tomography (CT) revealed a well-defined nodular mass in the po...
We describe a case of an extramedullary plasmacytoma (EMP) in an HIV‐positive child. An 11‐ year‐old, HIV‐infected female patient, on antiretroviral therapy since 2010, was referred with difficult to control asthma and bronchiectasis. The lesion was identified on CT chest following persisting reduced air entry and unilateral wheezing on the right. Rigid bronchoscopy identified a large pedunculated fleshy mass in the right main bronchus. Biopsy revealed it to be a plasmacytoma. Right main bronchus sleeve resection was done with complete removal of the tumor. Histology confirmed it to be a solitary plasmacytoma local...
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