Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison
The objective of the current study was to further elucidate the metabolic pathways of lenvatinib in humans and to compare these results to the metabolism in rats and monkeys. To this end, we used plasma, urine and feces collected in a human mass balance study after a single 24 mg (100 μCi) oral dose of 14C-lenvatinib. Metabolites of 14C-lenvatinib were identified using liquid chromatography (high resolution) mass spectrometry with off-line radioactivity detection. Close to 50 lenvatinib-related compounds were detected. In humans, unchanged lenvatinib accounted for 97 % of the radioactivity in plasma, and comprised 0.38 and 2.5 % of the administered dose excreted in urine and feces, respectively. The primary biotransformation pathways of lenvatinib were hydrolysis, oxidation and hydroxylation, N-oxidation, dealkylation and glucuronidation. Various combinations of these conversions with modifications, including hydrolysis, gluthathione/cysteine conjugation, intramolecular rearrangement and dimerization, were observed. Some metabolites seem to be unique to the investigated species (human, rat, monkey). Because all lenvatinib metabolites in human plasma were at very low levels compared to lenvatinib, only lenvatinib is expected to contribute to the pharmacological effects in humans.
Publication date: Available online 18 January 2020Source: The American Journal of SurgeryAuthor(s): Asishana A. Osho, Muath M. Bishawi, Elbert E. Heng, Ejiro Orubu, Aaron Amardey-Wellington, Mauricio A. Villavicencio, Masaki FunamotoAbstractBackgroundFailure to Rescue (FTR) is a valuable surgical quality improvement metric. The aim of this study is to assess the relationship between center volume and FTR following lung transplantation.MethodsUsing the database of the United Network for Organ Sharing (UNOS) all adult, primary, isolated lung recipients in the United States between May 2005 and March 2016 were identified. FTR...
ConclusionOverall, these guidelines provide consistent recommendations on who should receive breast reconstruction education, who is a candidate for postmastectomy breast reconstruction, and the appropriate timing of reconstruction and extent of mastectomy. Future updates from all should focus on expanding to include alloplastic and autologous forms of reconstruction and should include a broad scope of relevant questions.
Publication date: Available online 18 January 2020Source: European Journal of Surgical OncologyAuthor(s): Emrullah Birgin, Erik Rasbach, Christoph Reissfelder, Nuh N. RahbariAbstractBackgroundSurgical resection remains the only potentially curative therapy for hilar cholangiocarcinoma (CCC) patients. This meta-analysis aimed to review the current evidence on perioperative and long-term outcomes of routine caudate lobe resection (CLR) for surgical treatment of hilar CCC.MethodsA systematic literature search using MEDLINE, EMBASE and Cochrane databases was performed for studies providing comparative data on perioperative and...
I tried searching but couldn't find a relevant thread. I was wondering if anyone has experience with a hospital employed job that compensates in "collections minus expenses." How exactly does this work in a hospital setting? The hospital is still getting the facility fee for each clinic visit (hospital clinic)/procedure - so I'm not really clear on what "expenses" are typically attributed to the physician. Can anyone share their pay structure with this kind of system?
PCOM branch campus Moultrie GA - opened 2019 Noorda COM Provo UT - planned opening 2021 https://rm.edu/about-the-university/university-news/rmuohp-news/ground-broken-for-new-medical-education-and-research-campus-in-provo/ Kiran Patel COM Clearwater FL - opened 2019 MNCOM Gaylord MN - planned 2021 opening https://osteopathic.org/wp-content/uploads/com-candidate-status.pdf Sam Houston State University COM Conroe TX... Whoot! Whoot! Update: 13 New Schools Beginning in 2019
Hi all, I’m looking for examples of physician scientists who went directly to a research faculty position upon completion of their degrees. I personally anticipate that I will want to complete a residency, but I’m curious to read the profiles and paths of people who went straight to faculty. Thanks in advance!
THIRD YEAR ICOM’s third-year osteopathic medical students will be required to complete 12 core rotations. The required rotations for third year are listed below; all core rotations must be taken and completed at ICOM core rotation sites. Core rotations are clinical rotations involving patient care which are required to be completed at a ICOM affiliated clinical site with ICOM faculty. Clinical Education — Idaho College of Osteopathic Medicine www.idahocom.org [ATTACH....
I was accepted to LECOM and U of Pitt Dental schools. I like both schools, but am having a hard time deciding on the one that's right for me. Can someone give me some insight on pros and cons of each school..
To those experienced does your private practice continue to grow every year if you allowed it to and at what point since starting your business did you feel you sort of hit your peak .... ex 3,4,5+ years into it? As a younger person who is now in my 4th year ( attending) I always feel a bit like hmm I "hope" I will be able to have the same or better business as the previous year and I have been lucky or in the right area that it has increased year after year. Just wondered if others who... Private Practice Growth?
I am fortunate enough to have received offers from some of my top choices this cycle and would appreciate input from current applicants, medical students, and/or physicians about making a decision. To assist in this: my career interests include health policy, outcomes research, and public health. I can see myself specializing in a surgical subspecialty (e.g. Urology, ENT) or Emergency Medicine. I am a CA resident and would like to eventually practice here. To keep things consistent, I have... UCSF vs. NYU vs. Johns Hopkins