Rheumatoid Arthritis Progression Rate Has Halved Since 1990 Rheumatoid Arthritis Progression Rate Has Halved Since 1990
The rate of radiographic progression in RA has decreased during the last 20 years, in tandem with changes in RA treatment practices. Medscape Medical News
Conclusion: Wrist arthrodesis using an LCP metaphyseal plate was favorable for rheumatoid arthritis patients with comparable stability to that of and a lower risk of plate-related complications than an AO wrist fusion plate. PMID: 30112006 [PubMed]
Condition: Rheumatoid Arthritis (RA) Intervention: Diagnostic Test: Vectra DA Sponsor: Myriad Genetic Laboratories, Inc. Not yet recruiting
CONCLUSIONS: Early and strict synovitis suppression with methotrexate and intra-articular glucocorticoids led to persistently high remission rates and limited erosive progression at 11 years. In this well-treated cohort, baseline anti-CCP status, DAS28, and MRI bone marrow oedema predicted functional status and/or erosive progression. PMID: 30101636 [PubMed - as supplied by publisher]
Arthritis&Rheumatology,Volume 0, Issue ja, -Not available-.
AbstractSummaryThe incidence of atypical femoral fractures (AFFs) was 2.95% among 6644 hip and femoral fractures. Independent risk factors included the use of bisphosphonates (BPs), osteopenia or osteoporosis, rheumatoid arthritis, increased femoral curvatures, and thicker femoral cortices. Patients with AFFs and BP treatment were more likely to have problematic healing than those with typical femoral fractures (TFFs) and no BP treatment.IntroductionTo determine the incidence and risk factors of atypical femoral fractures (AFFs), we performed a multicenter case-control study. We also investigated the effects of bisphosphon...
ConclusionSignificant associations between LRP5 SNPs (p.A1330V, p.N740N, and p.V667M) and the severity of radiographic damage reinforce the evidence of bone destruction heritability in RA.
ConclusionOdontoid pannus formation is rare in AS. Clinical and radiological follow-up are important to assess the impact on the cervical spine.
This study involved eighty RA patients divided equally according to rheumatoid factor (RF) positivity. Modified Health Assessment Questionnaire, disease activity score in 28-joints (DAS 28), visual analogue scale of pain, Short Form Health Survey for mental and physical health, fibromyalgia questionnaire, RA Articular Damage score and radiological joint damage by van der Heijde modification were assessed. Serum level for serotonin was measured for all patients.ResultsThe mean age of seronegative patients was 41.7 ± 10.7 years; 36 females and 4 males and of seropositive (44.9 ± 12.9&nb...
This study aimed to understand the correlation between perceived and observed function, strength, and alignment.MethodsCross-sectional study including all 11 women (15 hands) submitted to second to fifth metacarpophalangeal joint arthroplasty due to rheumatoid arthritis involvement for a time period of seven years. Measurements relied on the Michigan Hand Outcomes Questionnaire, Lafayette Purdue Pegboard, pinch and grip strength, and analysis of a lateral “OK-sign” X-ray view. Correlation analysis used Spearman's coefficient, assuming statistical significance for p-values
ConclusionThese results indicate that EG extract and fractions significantly attenuated adjuvant arthritis in rats by decreasing the levels of aforementioned pro-inflammatory and increasing the levels of anti-inflammatory mediators. This suggests that Ephedra gerardiana aerial parts might be used as a therapeutic agent for treating human arthritis.Graphical abstract