Pharmacokinetic variation

Publication date: Available online 23 February 2016 Source:Anaesthesia & Intensive Care Medicine Author(s): Marc Chikhani, Jonathan G. Hardman Pharmacokinetics is the study of how a drug is handled within the body. Variation in drug absorption, distribution, metabolism or excretion will alter drug concentration at the target site. Appreciation of the principle causes of pharmacokinetic variation will ensure avoidance of sub-therapeutic drug regimes and unnecessary side effects through over-dosage. The processes of absorption, distribution, metabolism and excretion can be affected by a number of physiological, pathological and pharmacological factors.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research