Life cycle assessment of multi-step rufinamide synthesis - from isolated reactions in batch to continuous microreactor networks

Green Chem., 2016, 18,1096-1116DOI: 10.1039/C5GC01932J, PaperDenise Ott, Svetlana Borukhova, Volker HesselRufinamide is an antiepileptic drug to treat Lennox-Gastaut syndrome, in combination with other medications. Herein, several batch and continuous process routes to rufinamide are analysed and optimised regarding their environmental impact, to finally predict a fully continuous, telescoped process route.The content of this RSS Feed (c) The Royal Society of Chemistry
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