Cytotoxic polycyclic polyprenylated acylphloroglucinol derivatives and xanthones from Hypericum attenuatum

Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Zhong-Bo Zhou, Yang-Mei Zhang, Jian-Guang Luo, Ling-Yi Kong Two new polycyclic polyprenylated acylphloroglucinols, attenuatumione G (1) and attenuatumione H (2), together with five known compounds (3–7) have been isolated from the whole plant of Hypericum attenuatum. Their structures were elucidated by spectroscopic data including HRESIMS, 1D- and 2D-NMR. In biological assays, compound 2 showed moderate cytotoxic activities against Hep-G2 (IC50 9.11μM) and MCF-7 (IC50 16.24μM), compound 4 exhibited significant cytotoxic activity with IC50 value of 5.32μM against Hep-G2, and both compounds 5 and 6 revealed significant nitric oxide production inhibitory activity with IC50 values of 5.52 and 8.46μM, respectively. Graphical abstract

Source: Phytochemistry Letters - February 12, 2016 Category: Chemistry Source Type: research