NF-κB inhibitory activities of triterpenoid glycosides from the stems of Acanthopanax senticosus (Rupr. & Maxim.) Harms

Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Na Li, Ya-Nan Sun, Le Zhang, Zhen-Dong Tuo, Jia-Lin Li, Pei-Ge Du, Long Cui Three new triterpenoid glycosides, 3β-hydroxy-28-norolean-12-ene-16-one 3-O-β-d-glucopyranoside (1), 3β,17β-dihydroxy-28-norolean-12-ene-16-one 3-O-β-d-glucopyranoside (2) and 3β-hydroxy-olean-12-ene-16,28-lactone 3-O-β-d-glucopyranoside (3) together with eclalbasaponin II (4) were isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. Inhibition of NF-κB of these isolates was measured in HepG2 cells using a luciferase reporter system. Among the isolates, compounds 1, 2 and 4 inhibited NF-κB activation stimulated by TNF-α in a dose-dependent manner, with IC50 values ranging from 8.3±0.7 to 13.5±1.0μM. Graphical abstract

Source: Phytochemistry Letters - January 25, 2016 Category: Chemistry Source Type: research