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Ticks that transmit Lyme disease reported in nearly half of all US counties

Lyme disease is transmitted by the blacklegged tick (Ixodes scapularis) and the western blacklegged tick (Ixodes pacificus), and the range of these ticks is spreading, according to new research.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Updated Date: Dec 11, 2017 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Dec 11, 2017 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Non-human primates currently serve as the best experimental model for Lyme disease due to their close genetic homology with humans and demonstration of all three phases of disease following infection with Borreliella (Borrelia) burgdorferi (Bb). We investigated the pathology associated with late disseminated Lyme disease (12 to 13 months following tick inoculation) in doxycycline-treated (28 days; 5mg/kg, oral, 2x/day) and untreated rhesus macaques (Rm). Minimal to moderate lymphoplasmacytic inflammation, with a predilection for perivascular spaces and collagenous tissues, was observed in multiple tissues including the cer...
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research
Publication date: Available online 10 December 2017 Source:Ticks and Tick-borne Diseases Author(s): Christine B. Graham, Sarah E. Maes, Andrias Hojgaard, Amy C. Fleshman, Sarah W. Sheldon, Rebecca J. Eisen The incidence and geographic range of tick-borne illness associated with Ixodes scapularis and Ixodes pacificus have dramatically increased in recent decades. Anaplasmosis, babesiosis, and Borrelia spirochete infections, including Lyme borreliosis, account for tens of thousands of reported cases of tick-borne disease every year. Assays that reliably detect pathogens in ticks allow investigators and public health agencie...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Authors: Paparone PW Abstract Preview The presentation of Lyme disease may resemble that of polymyalgia rheumatica. What's more, the latter may occur in patients who have positive serologic findings for the former. In this case report, the author describes differential diagnosis in an elderly patient whose rheumatic complaints and blood chemistry profile alone could easily have led to misdiagnosis. Important points in evaluation and treatment are discussed. PMID: 29219773 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Masters EJ Abstract Preview Because disseminated Lyme disease can be devastating, early recognition and treatment are important. The presence of erythema migrans offers the best opportunity for early diagnosis. Therefore, public awareness and patient education about the rash of Lyme disease are critical. Dr Masters gives practical pointers from his own experience in evaluation of erythema migrans and reviews current treatment recommendations. PMID: 29219679 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Check out some of the recent highlights from NEJM Group: NEJM: Perspective: Dr. Margot Kushel examines the root cause of a hepatitis A outbreak in...
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news
(Rutgers University) New diagnostic methods offer a better chance for more accurate detection of the infection from the Lyme bacteria, the most common tick-borne infection in North America and Europe.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Rapid diagnosis of Lyme borreliosis has been carried out on chemically modified porous polyethylene sinter bodies. Photografting of 2-propenol on sinter body's surface was performed as a first step, introducing active hydroxyl groups as a result of polyalcohol formation. The hydroxyl groups were used for further immobilization and could be linked via 3-aminopropyltriethoxysilane (APTES) to polysaccharides like mannan. Prone to coupling, mannan was activated using N, N'-disuccinimidyl carbonate (DSC) to allow smooth reaction with the primary amine groups of the silane layer. In a final preparation step, a ...
Source: Analytical Biochemistry - Category: Biochemistry Authors: Tags: Anal Biochem Source Type: research
The objective of the present study was to examine the interaction of skin fibroblasts withB. burgdorferi sensu stricto B31 (BB) andB. afzelii (BA) in vitro by electron microscopy. We also determined the expression of collagen type I, TGF- β, FGF-1, calreticulin (CALR), decorin (DCN), and PDGF-α at the mRNA level inBorrelia/fibroblast co-cultures. IntactBorrelia attach to and transmigrate fibroblasts, and undergo cystic transformation outside the fibroblasts. Fibroblasts preserve their vitality and express a prominent granular endoplasmic reticulum, suggesting activated protein synthesis. On two different semi-qu...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
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