Effect of bone morphogenetic protein-4 on in vitro growth, steroidogenesis and subsequent developmental competence of the oocyte-granulosa cell complex derived from bovine early antral follicles.

CONCLUSIONS: BMP-4 addition during in vitro growth culture suppressed progesterone production and decreased the diameter of granulosa cells, suggesting its effect on steroidogenesis; importantly, it did not affect oocyte growth, nuclear maturation and fertilization. However, BMP-4 impaired subsequent embryonic development, and in higher concentration (50 ng/mL) even compromised OGC viability by suppressing proliferation of granulosa cells.
PMID: 26769429 [PubMed - in process]

Source: Reproductive Biology - January 18, 2016 Category: Reproduction Medicine Authors: Yang Y, Kanno C, Huang W, Kang SS, Yanagawa Y, Nagano M Tags: Reprod Biol Endocrinol Source Type: research