99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans

Publication date: Available online 23 October 2015 Source:The Egyptian Journal of Radiology and Nuclear Medicine Author(s): Aniqa Jabeen, Hassan Raza, Bashir Ahmed, S. Minhaj Maqbool, Sumaira Mushtaq, Lubna Khan Jadoon, Mussaratulain, Mohammd Ali Memon The aim of study was to evaluate the effectiveness of 99mTc-MIBI (hexakis 2-methoxyisobutyl isonitrile) scintigraphy to differentiate malignant from benign lesions, detected on 99mTc-MDP planar bone scans. 59 patients with bony lesions were studied prospectively and compared with histopathology. Each patient underwent a 99mTc-MDP scan, and if evidence of lesion found, patient underwent 99mTc-MIBI scintigraphy after three to four days. 99mTc-MIBI scans were evaluated visually and quantitatively. For quantitative analysis count ratio of lesion to contralateral normal side (L/C) was taken and Student T test was applied. 99mTc-MDP scans showed increase tracer uptake but no significant difference between benign and malignant uptake was seen. Significant difference (p value 0.015), was seen in malignant (L/C 3.51±1.02) and benign lesions (L/C 2.50±0.42) on 99mTc-MIBI scan. Three of thirty benign lesions did not show significant 99mTc-MIBI uptake. Six malignant lesions appeared as false negatives. Specificity of 99mTc-MIBI was 86.66%, Negative Predictive Value (NPV) 81.25% whereas the sensitivity was 79.31%. 99mTc-MIBI scintigraphy provides its usefulness by distinguishing malignant from benign lesions along wi...
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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