Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code.

CONCLUSIONS: When the geant 4 particle tracking method is used to calculate the average LET values within targets with a small step limit, such as smaller than 500 μm, the authors recommend the use of LETt in the dose plateau region and LETd around the Bragg peak. For a large step limit, i.e., 500 μm, LETd is recommended along the whole Bragg curve. The transition point depends on beam parameters and can be found by determining the location where the gradient of the ratio of LETd and LETt becomes positive.
PMID: 26520716 [PubMed - in process]

Source: Physica Medica - November 1, 2015 Category: Physics Authors: Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U Tags: Med Phys Source Type: research