Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice.

Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice.
Hear Res. 2015 Sep 28;
Authors: Toal KL, Radziwon KE, Holfoth DP, Xu-Friedman MA, Dent ML
Abstract
The cannabinoid receptor 1 (CB1R) is found at several stages in the auditory pathway, but its role in hearing is unknown. Hearing abilities were measured in CB1R knockout mice and compared to those of wild-type mice. Operant conditioning and the psychophysical Method of Constant Stimuli were used to measure audiograms, gap detection thresholds, and frequency difference limens in trained mice using the same methods and stimuli as in previous experiments. CB1R knockout mice showed deficits at frequencies above 8 kHz in their audiograms relative to wild-type mice. CB1R knockouts showed enhancements for detecting gaps in low-pass noisebursts relative to wild-type mice, but were similar for other noise conditions. Finally, the two groups of mice did not differ in their frequency discrimination abilities as measured by the frequency difference limens task. These experiments suggest that the CB1R is involved in auditory processing and lay the groundwork for future physiological experiments.
PMID: 26427583 [PubMed - as supplied by publisher]

Source: Hearing Research - September 28, 2015 Category: Audiology Authors: Toal KL, Radziwon KE, Holfoth DP, Xu-Friedman MA, Dent ML Tags: Hear Res Source Type: research