The rate of glycolysis quantitatively mediates specific histone acetylation sites

Conclusions We demonstrate that histone acylation is directly sensed by glucose flux in a titratable, dose-dependent manner that is modulated by glycolytic flux and that a possible function of the Warburg Effect, a metabolic state observed in cancers with enhanced glucose metabolism, is to confer specific signaling effects on cells.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research