Participation in Juvenile Idiopathic Arthritis.
Participation in Juvenile Idiopathic Arthritis. J Rheumatol. 2015 Sep;42(9):1545-7 Authors: Houghton KM PMID: 26330125 [PubMed - in process]
This study summarizes some of the concerns of MRI use in the orthopedic community and attempts to add a unique perspective on the attitudes, decision-making, and apparent economic problems that they face as well as uncover specific instances where MRIs were determined to be unreliable and incomplete in aiding the diagnosis and treatment algorithm. PMID: 31523134 [PubMed]
Authors: Martinez-Prat L, Palterer B, Vitiello G, Parronchi P, Robinson WH, Mahler M Abstract Introduction: The protein-arginine deiminase (PAD) 4 enzyme plays an important role in the pathogenesis of rheumatoid arthritis (RA) and also represents an antigenic target. Anti-PAD4 antibodies can be present in RA and are associated with specific clinical features. Areas covered: This review aims to analyze the current knowledge and recent findings on anti-PAD4 antibodies in RA and their clinical and immunological significance. Expert opinion: Anti-PAD4 antibodies aren't currently used in clinical practice for the manage...
ConclusionGroup B streptococcal infection might become invasive in immunocompromised patients, so careful follow-up for those patients is important.
CONCLUSIONS Intraarticular vancomycin and teicoplanin maximale tolerable and maintenance doses can be safely used beside surgery and intravenous antibiotics to increase efficacy of treatment, reduction of recurrence rates and reduction of mortality in MRSA septic arthritis. Key words:arthritis, infectious; methicillin-resistant Staphylococcus aureus; mortality. PMID: 31524589 [PubMed - in process]
Accumulating studies have suggested that long non-coding RNAs (lncRNAs) have drawn more and more attention in rheumatoid arthritis (RA), which can function as competitive endogenous RNAs (ceRNAs) in inflammation and immune disorders. Previously, we have found that lncRNA HIX003209 is differentially expressed in RA. However, the precise mechanism of lncRNA HIX003209 in RA is still vague. We aim to elucidate the role and its targeted microRNA of lncRNA HIX003209 in RA as ceRNA. Significantly increased expression of lncRNA HIX003209 was observed in the peripheral blood mononuclear cells (PBMCs) from RA cases. It was positivel...
Publication date: Available online 17 September 2019Source: Reumatología Clínica (English Edition)Author(s): Carola Baliu-Piqué, Elena Nogués-Antich, Marta Cucurell-Palomas, Dolors Grados
Publication date: Available online 16 September 2019Source: Pharmacological ResearchAuthor(s): Fabiola Atzeni, Valeria Nucera, Ignazio Francesco Masala, Piercarlo Sarzi-Puttini, Gianluca BonittaABSTRACTInterleukin 6 (IL-6) is a pleiotropic cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and also mediates communications between the immune and central nervous system (CNS). Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating ...
ConclusionTGP can not only improve symptoms, but also inhibit bone destruction. The therapeutic effect of TGP on CIA is mainly achieved by inhibiting spleen Tfh cell differentiation and GC formation through STAT3 signaling pathway.Graphical Abstract
Condition: Rheumatoid Arthritis Intervention: Diagnostic Test: CTHRC1 biomarker Sponsor: Assiut University Not yet recruiting
A 32-year-old male patient with rheumatoid arthritis affecting multiple joints without rheumatoid factor returns to the office for a follow-up visit with the nurse practitioner (NP). The patient states his overall pain has improved since his previous visit, although he rates the severity of his right shoulder and right wrist pain at a 5 on... [Read More]