Autophagosomes and lipid droplets: no longer just chewing the fat

Autophagosomes are organelles capable of sequestering and degrading diverse cytoplasmic cargo for nutritional and quality control purposes. Targeted are also lipid droplets (LDs), the cytoplasmic stores of neutral lipids. In this issue of The EMBO Journal, Shpilka et al (2015) show that the relationship between LDs and autophagosomes is far more intricate and that LDs regulate autophagosome biogenesis.

Source: EMBO Journal - August 12, 2015 Category: Molecular Biology Authors: Deretic, V. Tags: Autophagy & Cell Death, Metabolism News [amp ] Views Source Type: research