Beneficial Impact of bFGF Antisense Therapy in a Rat Model of Pulmonary Fibrosis.

CONCLUSIONS: bFGF appears to promote collagen I synthesis and upregulates TGF-β1/Smad signaling to promote lung fibroblast proliferation and differentiation in pulmonary fibrosis. bFGF antisense oligonucleotide therapy shows promise in preventing the development of pulmonary fibrosis, likely though a TGF-β1/Smad-based signaling mechanism. PMID: 26237352 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research