Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies

Localization of causal variants underlying known risk loci is one of the main research challenges following genome-wide association studies. Risk loci are typically dissected through fine-mapping experiments in trans-ethnic cohorts for leveraging the variability in the local genetic structure across populations. More recent works have shown that genomic functional annotations (i.e., localization of tissue-specific regulatory marks) can be integrated for increasing fine-mapping performance within single-population studies.

Source: The American Journal of Human Genetics - July 16, 2015 Category: Genetics & Stem Cells Authors: Gleb Kichaev, Bogdan Pasaniuc Tags: Article Source Type: research